Enhancement of diffusion-controlled reaction rates by surface-induced orientational restriction.
نویسندگان
چکیده
We explore the means by which immobilization of a substrate on a surface can increase the rate of a diffusion-controlled enzymatic reaction. A quasichemical approach is developed and compared with Brownian dynamics simulations. We use these methods to show that restricting only the orientation of the enzyme by long-range interactions with the surface is sufficient for enhancing catalysis.
منابع مشابه
Diffusion Controlled Effective Reaction Rate for a Surface Reaction with Orientational Selectivity
für Naturforschung in cooperation with the Max Planck Society for the Advancement of Science under a Creative Commons Attribution 4.0 International License. Dieses Werk wurde im Jahr 2013 vom Verlag Zeitschrift für Naturforschung in Zusammenarbeit mit der Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. digitalisiert und unter folgender Lizenz veröffentlicht: Creative Commons Namen...
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ورودعنوان ژورنال:
- Biophysical journal
دوره 90 3 شماره
صفحات -
تاریخ انتشار 2006